Most recently Fang et al. [142] examined case histories of 193 patients with clinically localized PCa, a Gleason score ≥7 and/or a PSA level of ≥10 ng/mL treated with 103Pd brachytherapy and supplemental external beam radiotherapy (EBRT) between 1992 and 1996. Here, KLK3 is linked to posterior cortical atrophy.