The clinical usefulness of CA125 in diagnosis of pancreatic cancer is further limited, because 64% of patients with liver cirrhosis, 23% of patients with hepatitis, 25%–38% of patients with pancreatitis, and 35% of patients with jaundice also have increased levels of CA125 [8,55] (Figure 1). The gene discussed is MUC16; the disease is familial pancreatic carcinoma.