SKP2 and neoplasm: Interestingly, a tissue microarray study by Voduc and colleagues [138] that investigated the combinatorial overexpression of Skp2 and cyclin E in breast cancer was able to confirm the association with the basal-like subtype and prognostic significance in univariable but not multivariable analysis (taking into account standard clinicopathologic variables, such as patient age, tumor size, tumor grade and nodal status).