Interestingly, a tissue microarray study by Voduc and colleagues [138] that investigated the combinatorial overexpression of Skp2 and cyclin E in breast cancer was able to confirm the association with the basal-like subtype and prognostic significance in univariable but not multivariable analysis (taking into account standard clinicopathologic variables, such as patient age, tumor size, tumor grade and nodal status). This evidence concerns the gene CCNE1 and breast carcinoma.