In previously untreated patients with metastatic colorectal cancer responses to vatalanib plus chemotherapy correlated directly with tissue messenger RNA levels of VEGFR1, LDHA (lactate dehydrogenase A) and Glut1 and inversely with hypoxia-inducible factor 1α (HIF1α1) [30]. The gene discussed is LDHA; the disease is metastatic colorectal cancer.