In the absence of Wnt ligand, a “destruction” complex consisting of the three proteins AXIN, glycogen synthase kinase 3-β (GSK3B), and APC (the gene responsible for familial adenomatous polyposi colorectal cancer) constitutively targets the β-catenin protein for proteasomal degradation. The gene discussed is GSK3B; the disease is Familial adenomatous polyposis.