PTGS2 and ovarian carcinoma: Wnt signaling results in phosphorylation of cytosolic β-catenin by Gsk-3β which leads to nuclear accumulation and trancriptional activation of target genes such as Cox-2 and cyclin D. The nuclear presence of β-catenin is significantly different among the histopatholgies of ovarian cancer [17,224] and also correlated to better survival of patients [220,224].