➢Loss of expression of Pten in mice results in aberrant self-renewal of HSCs and eventually leukemia [163].➢Loss of Pten eventually leads to myelo-proliferative disease and the emergence of a transplantable leukemia.➢Mutations and/or loss of heterogeneity of Pten can cause glioblastoma, prostate, and endometrial carcinoma [164]. The gene discussed is PTEN; the disease is endometrial carcinoma.