In addition to angiogenic activity, recent investigations have reported that IL-8 plays a key role in gliomagenesis probably because it acts as inflammatory chemoattractant as part of the host response to neoplasia and it represents a more general pro-inflammatory autocrine and paracrine growth factor released in response to tissue stress and necrosis, promoting development of neoplasia. This evidence concerns the gene CXCL8 and neoplasm.