Nevertheless, implantation of a fast growing tumour in mice (Lewis lung carcinoma) resulted in a clear cachectic state accompanied by a significant increase in both UCP2 and UCP3 gene expression in skeletal muscle and heart, whithout a rise in circulating fatty acids or a decrease in food intake, questioning hyperlipaemia as the only factor controlling UCP2-3 expression in cancer cachexia [138]. The gene discussed is UCP2; the disease is cancer.