By evaluating the expression of bFGF, VEGF and MMP-2 in metastatic tumors derived from melanoma cell lines with STAT3 activation altered, we established that STAT3 activation has, as expected, a direct correlation with increased expression of these angiogenic molecules and corresponding increases in tumor microvessel density as demonstrated on immunohistochemistry [50]. This evidence concerns the gene STAT3 and neoplasm.