In B16M-F10 cells interacting with endothelial cells, H2O2- and NO-induced adaptations include cell adhesion molecule expression in both endothelial and cancer cells (see above), activation of the early growth response-1 transcription factor gene, activation of cancer and endothelial cell MMPs, increase of antioxidant enzymes such as MnSOD and catalase, and induction of key invasive growth-related molecules such as VEGF-A, HIF-1 and protein 8 [159,186]. The gene discussed is HIF1A; the disease is cancer.