Moreover, although high NO levels down-regulate the antiapoptotic protein Bcl-2 and induce cytotoxicity in e.g., B16M-F10 cells [187], low NO levels induce S-nitrosylation of Bcl-2, which inhibits its ubiquitination and subsequent proteosomal degradation in, for example, lung cancer cells. The gene discussed is BCL2; the disease is lung cancer.