Figure 1A shows a heatmap for upregulated extracellular matrix related genes from this analysis. The mRNA expression profiles of periostin and lumican across the samples are shown in Figure 1B. On average, POSTN was upregulated 11-fold whereas LUM was upregulated 7-fold in ESCC as compared to the adjacent normal epithelia. Figure 1C shows a heatmap for downregulated extracellular matrix related genes from this analysis. Here, LUM is linked to esophageal squamous cell carcinoma.