COL18A1 and neoplasm: Moreover, in a murine melanoma brain metastatic model, melanoma expressing endostatin displayed a reduced capacity to recruit an adequate vascular micrometastases supply [114] and injection of endostatin-recombinant plasmid into B16 melanoma in C57BL/6J mice followed by local x-irradiation inhibited tumor growth with a marked decrease of intratumoral vascularization [115].