This platform assays more than 480 000 CpG sites at single base resolution (covering 99% of RefSeq genes and 96% of CpG islands (CGIs)).16 We demonstrate that DNAm profiles in AML reveal frequent hypermethylation at an internal promoter region of DNMT3A, which was not observed in normal blood. Here, DNMT3A is linked to acute myeloid leukemia.