In analogy to DNMT3A mutations, the epimutations were not found in core-binding factor-AMLs (defined by RUNX1-RUNX1T1 or CBFB-MYH11 fusion) and only very rarely in acute promyelocytic leukemia (PML-PARA fusion).25 On the other hand, mutations as well as epimutations in DNMT3A were highly significantly associated with mutations of IDH1, IDH2, RUNX1 and NPM1 (Supplementary Figure 10). Here, RUNX1 is linked to acute promyelocytic leukemia.