Indeed, hypermethylation within the gene DNMT3A was associated with significantly shorter event-free survival (Figure 4) and shorter OS (Supplementary Figure 17) in the data set of TCGA.9 However, such a pronounced effect could not be recapitulated in our own data set, which can likely be attributed to the relatively small set of 88 AML samples. This evidence concerns the gene DNMT3A and acute myeloid leukemia.