The DNAm level at DMR2 was significantly higher in AML samples without epimutation, but both modifications were significantly associated with mutations of IDH1, IDH2, RUNX1 and NPM1. Epimutations and mutations in DNMT3A were enriched in AML samples with an intermediate or poor cytogenetic risk. The gene discussed is RUNX1; the disease is acute myeloid leukemia.