Furthermore, when the wild-type (WT) caspase-3 (Casp3WT) or its catalytically inactive mutant was fused to TAT-ODD and IP injected to a tumor-bearing mouse, the size of tumors was reduced by the administration of TAT-ODD-Casp3WT but not by TAT-ODD-mutant Casp3 [53]. This evidence concerns the gene CASP3 and neoplasm.