Consequently, major efforts have been directed toward the identification and characterization of different epigenetic regulators whose phenotypes have been altered in tumor cell lines with the goal of identifying potential therapeutic targets, including DNA-methyltransferases [16,17,18], histone acetyltransferases/deacetylases [17,19,20,21,22,23,24], and histone methyltransferases/demethylases [25,26,27,28,29], for the development of more efficient cancer treatment strategies. The gene discussed is MBD2; the disease is cancer.