HSP90AB1 and cancer: In this context, it was shown that Hsp90 in cancer cells (BT474, N87, SKOV3, and SkBr3; average IC50 ~5 nM) has a higher affinity for ligands than Hsp90 in normal cells (normal dermal fibroblasts, human renal epithelial cells, HMVEC, HUVEC, Hs578Bst, and PBMC; average IC50 ~943 nM).