TRPV1 and Fever: Because antagonist-induced hyperthermia is an on-target effect and a hurdle for the development of TRPV1 antagonists as therapeutics, future clinical trials of this class of molecules may include the following: (i) a preference to develop TRPV1 antagonists with shorter half-lives; (ii) co-dosing with antipyretic agents such as acetaminophen; and/or (iii) exclusion of patients susceptible to frequent pyrexia [110].