In wild type BCR-ABL or BCR-ABL-T315I mutant induced CML mice [32], we also observed that treatment with IPI-504 alone significantly prolonged the survival of mice with wild-type BCR-ABL-induced CML, and this therapeutic effect was much more apparent in the survival of mice with BCR-ABL-T315I-induced CML [4]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.