17-DMAG is active when taken orally, and combination of 17-DMAG and the mitogen-activated protein kinase/ERK kinase 1/2 inhibitor potently induces apoptosis of imatinib resistant BCR-ABL expressing leukemia cells by sustained extracellular signal regulated kinase (ERK1/2) inactivation and B-cell lymphoma extra large (Bcl-xL) down-regulation [86]. The gene discussed is ABL1; the disease is leukemia.