Because TRAF2 is known to be a mediator of inflammatory cytokine-induced NF-κB activation [23] and reduced levels of EI24 resulted in the promotion of tumor invasiveness through NF-κB (Figure 4), we examined whether the increase in NF-κB transcriptional activity upon EI24 knockdown is mediated through activation of Complex I signaling. Here, EI24 is linked to neoplasm.