AKT1 and lung cancer: However, a subtle difference in Akt recovery were measured among these different lung cancer cell lines, e.g., while both NCI-H2126 and A549 showed a clear later time recovery of Akt phosphorylation at threonine (T) 308 (pAktT308) and serine (S) 473 (pAktS473) (Figs. 1B and 2B), NCI-H2023 exhibited recovery of pAktT308 only following gefitinib treatment.