Given a recent report detailing the widespread detection of tumor-specific AS160 phosphorylation in breast cancer biopsies [17], investigation of the AS160/GLUT4 axis and further identification of the upstream activating kinases in tumor cells will serve to clarify the role of AS160 deregulation in supporting the Warburg effect and the malignant phenotype. The gene discussed is TBC1D4; the disease is breast cancer.