PFKFB3 and cancer: Among the glycolytic enzymes that are induced in cancer are the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases (PFK-2/FBPase-2), a family of bifunctional enzymes that control the levels of fructose 2,6-bisphosphate (Fru-2,6-P2).