PCa is characterized by the deregulation of several signaling pathways including GH, prolactin, IL6, and the IGF/insulin axis (Roberts 2004, Monti et al. 2007, Cox et al. 2009, Culig 2011, Goffin et al. 2011, Culig & Puhr 2012, Nakonechnaya et al. 2013), which can induce SOCS2 expression (Trengove & Ward 2013). The gene discussed is SOCS2; the disease is posterior cortical atrophy.