Among a panel of other adipokines analyzed, adiponectin levels were increased more than 2-fold, and Fetuin A, insulin-like growth factor (IGF)-1, IGF binding protein (IGFBP)-1, retinol binding protein (RBP)4 and tissue inhibitor of metalloproteinase (TIMP)1 were decreased 2.5-, 25.0-, 2.5-, 3.0-, and 12-fold, respectively, in the FGFR4−/− mice bearing breast tumors (Figure 6A and inset). This evidence concerns the gene TIMP1 and breast neoplasm.