In 6dN cells, significant enrichment (p < 0.05) was found for transcripts involved in WNT signalling as well as angiogenesis, inflammation mediated by chemokines and cytokine signalling, Alzheimer disease-presenilin and TGF-β signalling (Figure 5B and Table 1). The gene discussed is TGFB1; the disease is early-onset autosomal dominant Alzheimer disease.