CD4 and diabetes mellitus: No association with diabetes has been described for miR-1307, miR-142-3p, miR-142-5p, miR-199a-5p and miR-342-3p; however, miR-142-5p and miR-142-3p have been reported as negative regulators of CD4 T cells, and increased expression of miR-142-5p and miR-142-3p is reported in systemic lupus erythematosus, contributing to reverse T cell hyperactivity, inhibiting antibody production, reducing autoimmune activity and IgG production [44].