INS and diabetes mellitus: After the 40 days of administration of NCD, the mean plasma insulin level of diabetic rats (4.09 ± 0.45 μg/L) showed a significant (p < 0.001) increase compared to the diabetic level (0.65 ± 0.14 μg/L) which was followed by a further significant (p < 0.001) increase (5.26 ± 0.55 μg/L) after two months from the onset of diabetes.