Although a recent study has shown that a strong decrease in Cdc42 and Rac1 activity in combination with ROCK inhibition is clearly associated with increased colon cancer invasiveness [32], data from previous studies addressing the molecular mechanisms underlying colon cancer progression suggested that Rho family members including Cdc42 may play a critical role in promoting colon cancer progression [15]. The gene discussed is RAC1; the disease is malignant colon neoplasm.