To our knowledge, these four genes, which are related with the inflammatory response (CXCL1, CXCL2, CXCL3) or cell–matrix adhesion (ITGB5), have been isolated from the CCs of PCOS patients for the first time by cDNA microarray in our previous research[25]. The gene discussed is ITGB5; the disease is polycystic ovary syndrome.