Seven of these genes, [Runt-related transcription factor 2 (RUNX2), Phosphoserine aminotransferase 1 (PSAT1), ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), chemokine (C-X-C motif) ligand 1,2,3 (CXCL1, CXCL2, CXCL3), and integrin β5(ITGB5)] were chosen based on differences in their expression at different oocyte nuclear maturity stages (MII or MI) in cumulus cells of PCOS patients[25]. Here, ITGB5 is linked to polycystic ovary syndrome.