TRPM8 and migraine disorder: Certain success using this approach has been done in genetic research of common forms of migraine: four GWASs have successfully identified four new genetic variants including rs1835740 modulating glutamate homeostasis and specifically associated with more severe form (migraine with aura); rs11172113 involving the lipoprotein receptor LRP1; rs10166942 in close proximity to TRPM8, which codes for a cold pain sensitivity; and rs2651899 (PRDM16) with yet unclear role in migraine [205].