Three different formulations of beta-interferons which exist for treatment of MS consist of low dose IFN-β1a (Avonex) (30 micrograms intramuscular once weekly), high disease IFN-β1a [Rebif] (22 and 44 micrograms subcutaneously three times weekly), and IFN-β1b (Betaseron) (8,000,000 units 250 micrograms subcutaneously alternate day injection). The gene discussed is IFNB1; the disease is myeloid sarcoma.