TNFRSF11B and postmenopausal osteoporosis: From a therapeutic standpoint several studies have demonstrated the capacity of OPG suppression to ameliorate osteoporotic states and/or improve bone mass in ovariectomized animals (a model of postmenopausal osteoporosis) by means of adenoviral OPG delivery in mice [62], a single intravenous OPG injection in ovariectomized rats [63], weekly treatment of gonadal intact monkeys [64], and a single injection in postmenopausal women [65].