Despite the controversies related to sources of TF-bearing microparticles, there has been a growing body of evidence that this form of TF is associated with pathologic conditions, such as pulmonary embolism [116], venous thromboembolism [117], and disseminated intravascular coagulation [118], particularly in patients with various types of malignancy [118–122]. This evidence concerns the gene TF and pulmonary embolism.