The tumor suppressor PTEN (phosphatase and tensin homolog), which is often mutated in human leukemia, the proapoptotic and regulator of leukocyte homeostasis Bim (also known as BCL2-like 11), and the cyclin-dependent kinase inhibitor CDKN1A (p21), a potent negative regulator of the G1-S checkpoint, have been identified as additional relevant targets of the oncogenic miR-17-92 cluster [91, 93, 94]. Here, PTEN is linked to leukemia.