RUNX1 and acute promyelocytic leukemia: Many of these are chromosomal translocation involving hematopoietic transcription factors that produce oncogenic fusion proteins such as AML1–ETO (t(8; 21)), CBFβ-MYH11 (core-binding factor-β-myosin heavy chain 11; inv16), fusion proteins involving MLL (mixed lineage leukaemia; t11q23), and PML-RARα  (promyelocytic leukaemia-retinoic acid receptor-α; t(15; 17)).