In the remaining AMLs without apparent translocations, refer to as cytogenetically normal AMLs (CN-AML), a number of relevant molecular abnormalities have been described, such as the internal tandem duplication (ITD) or mutation of FMS-like tyrosine kinase 3 (FLT3) gene, mutations in nucleophosmin (NPM1), C/EBPα, and in the Wilms' tumour genes. Here, NPM1 is linked to acute myeloid leukemia.