By using global expression profiling and RT-PCR, Sato et al. identified epigenetic downregulation of the cyclin-dependant kinase inhibitor, CDKN1C/p57KIP2, in IPMN, which is also present in many pancreatic cancer cell lines [55]. The gene discussed is CDKN1C; the disease is pancreatic intraductal papillary-mucinous neoplasm.