INS and Hyperglycemia: Two compounds in particular, 4-phenyl butyric acid (PBA) and taurine-conjugated ursodeoxycholic acid (TUDCA), which are agents with known capacity to reduce ER stress, alleviated ER stress and resulted in normalization of hyperglycemia and restoration of systemic insulin sensitivity in these obese animals, thus altogether acting as potent antidiabetic agents [100, 129].