Pro-apoptotic CHOP, located opposite to GRP78 on the yin-yang balance of ER stress (Figure 1), generally is not conspicuously expressed in tumor tissues or tumor cell lines—despite low level, chronic ER stress conditions—because the pro-survival module maintains dominance and GRP78 acts to keep CHOP transcription low [93, 94]. The gene discussed is HSPA5; the disease is neoplasm.