One of the integral hallmarks of cancer is cancer cell survival, and curcumin is able to block this via a number of molecules with a clear involvement in survival mechanisms, several of which are NF-κB dependent such as cFLIP, BCL-xL, BCL-2, XIAP, CIAP1, CIAP2, and surviving [58–63]. This evidence concerns the gene BCL2L1 and cancer.