TNF and irritable bowel syndrome: Once overlooked, natural remedies such as curcumin are attracting increasing interest over the conventional mainstays of treatment that include 5-aminosalicylates (mesalamine), corticosteroids, immune modulators (e.g., methotrexate, azathioprine), biologic therapies such as anti-TNFα (infliximab, adalimumab), and anti-α4β7 antibodies (natalizumab) in IBD [32, 33].