Thus, exposure of human colon cancer cells to 4-hydroxy-2-nonenal caused nuclear accumulation of HSF1 and induced endogenous Hsp70 and Hsp40, as well as a luciferase reporter under the transcriptional control of the consensus HSE, and silencing of the expression of HSF1 by siRNA abolished this induction [72]. This evidence concerns the gene HSF1 and colonic neoplasm.