KEAP1 and neuroblastoma: Two recent high-throughput screens, one employing an ARE-dependent luciferase reporter to screen 1.2 million compounds in human neuroblastoma IMR-32 cells [143] and another utilizing a luciferase reporting on the stabilization of NRF2 which evaluated 20,000 biologically active compounds in human neuroblastoma SH-SY5Y-Neh2-luc cells [110], have confirmed that sulfhydryl reactivity is a prominent feature of inducers of the KEAP1/NRF2 pathway.