Under stimulation of the proinflammatory cytokine transforming growth factor-β (TGF-β), adipocytes synthesize TF in a small amount [58], and increased circulating levels of TF have been identified as a relevant factor involved in prothrombotic tendency of patients affected by high-grade obesity [59]. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.