INS and Abdominal obesity: Clear evidence of adipocyte-dependent TAFI synthesis is not available [101, 102]; however, several studies showed that the hormonal alterations related to central obesity influence the synthesis of this antifibrinolytic factor by other cell types: actually, insulin regulates TAFI gene expression in hepatocytes [102], and proinflammatory cytokines increase its production, inducing to consider this enzyme as an acute-phase reactant [103, 104].