SERPINE1 and metabolic syndrome: Although the relationship between fibrinogen and features of the insulin resistance syndrome is weaker than for other hemostatic factors such as PAI-1 and FVII [33, 48, 69, 70], epidemiological studies have consistently found a significant association between levels of fibrinogen and those of insulin [33]; on this basis, several studies enclosed the increase of fibrinogen in the cluster of cardiovascular risk factors of the metabolic syndrome [67, 69, 70].