The prevalence of activated platelets is usually associated to the increase of other prothrombotic proteins; in particular, some authors found, in patients with severe obesity and insulin resistance, increased levels of soluble CD40 ligand (sCD40L) [114–116], prothrombin fragment F1+2 [114–116], and platelet-derived microparticles (PMPs) [117]. The gene discussed is CD40LG; the disease is obesity due to melanocortin 4 receptor deficiency.