In this part of the paper some relevant data concerning several adipokines and cytokines recognized as involved in the derangement of the systemic hemostatic balance in patients with central obesity will be considered: in particular, leptin, ghrelin, adiponectin, and inflammatory cytokines considering their role in hemostatic balance, platelet function, and coagulative alterations characterizing central obesity. Here, GHRL is linked to Abdominal obesity.