APOB and Hypercholesterolemia: The drug, tested in monotherapy or in combination with conventional lipid-lowering therapy in homozygous FH [106] or in patients with hypercholesterolaemia (LDL-C 130–250 mg/dL) [107] showed a reduction in circulating LDL-C, apoB, total cholesterol, nonhigh-density lipoprotein cholesterol (non-HDL-C), and Lp(a) levels.