CER-001, a synthetic recombinant human apoA-I HDL mimetic, is in phase II testing in approximately 500 patients with acute coronary syndrome, to determine the effect on atherosclerotic plaque progression/regression as assessed by IVUS (CHI SQUARE; http://clinicaltrials.gov/ct2/show/NCT01201837). Here, APOA1 is linked to acute coronary syndrome.