Our findings suggest that the PPARG Pro12Ala/rs1801282 SNP may be of significant clinical interest, as it was associated with larger baseline waist circumference, larger visceral adipose tissue (VAT) area, and with all three longitudinal obesity metrics (greater short-term and long-term weight loss and greater tendency for weight regain) in the full DPP study sample, regardless of treatment group. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.