The authors reported a nominally statistically significant interaction between the TCF7L2 rs7903146 variant and dietary fiber intake in T2D risk (Pinteraction = 0.049), whereby the odds of developing diabetes conveyed by the TCF7L2 variant were lower (OR: 1.24, 95% CI 1.04, 1.47) in participants within the highest quartile of dietary fiber intake compared with those in the lowest quartile of fiber intake (OR: 1.56, 95% CI 1.31, 1.86). This evidence concerns the gene TCF7L2 and diabetes mellitus.