Aberrant expression of TRPM8 has been reported in neoplastic tissues, some of which include prostate carcinoma, breast adenocarcinoma, lung cancer, colorectal cancer, melanoma, urinary bladder cancer, neuroblastoma, neuroendocrine tumor [41–47], and in the most recent finding pancreatic adenocarcinoma [6, 8]. Here, TRPM8 is linked to pancreatic adenocarcinoma.