The focuses of our translational research studies are (i) to develop TRPM7 and TRPM8 channels as clinical biomarkers, with the goals of improving molecular phenotype of pancreatic tumor and predicting their response to treatment and (ii) to exploit TRPM7 and TRPM8 channels as therapeutic targets and also as ligands for directing tumor-specific delivery of anticancer therapeutics. The gene discussed is TRPM8; the disease is neoplasm.