INS and type 1 diabetes mellitus: This simulation environment was based on the previously introduced Meal Model of glucose-insulin dynamics [76, 77] and was equipped with a “population” of in silico images of N = 300 “subjects” with type 1 diabetes, separated in three age groups: N = 100 simulated “children” below the age of 11; N = 100 “adolescents” 12–18 years old and N = 100 “adults.” The characteristics of these “subjects” (e.g., weight, daily insulin dose, carbohydrate ratio, etc.)were tailored to span a wide range of intersubject variability approximating the variability observed in people in vivo [150].