HspB1 and/or HspB5 accumulate in cortical Lewy bodies, Alzheimer disease plaques, neurofibrillary tangles, Rosenthal fibers of Alexander's-disease, Creutzfeldt-Jakob altered neurones as well as in synuclein deposit associated to Parkinson's disease or myopathy-associated inclusion body [102–106]. The gene discussed is CRYAB; the disease is Parkinson disease.