CRYAB and amyotrophic lateral sclerosis: These facts were also confirmed by the discovery of mutations in HspB1, HspB5, and HspB8 genes that inhibit their chaperone activity and provoke human diseases such as inherited peripheral and motor neuropathies, amyotrophic lateral sclerosis (ALS), axonal Charcot-Marie-Tooth disease, myofibrillar myopathies, cardiomyopathies, and cataracts [119–125].