Furthermore, pretreatment of mice with CP-96345, an antagonist of the neurokinin-1 receptor (NK-1R) protected mice against lung inflammation caused by H2S. However, treatment with antagonists of NK-2, NK-3, and calcitonin gene related peptide (CGRP) receptors did not have any effect on H2S-induced lung inflammation. This evidence concerns the gene TAC1 and inflammatory response.