SAMSN1 and intracranial hypertension: The MTD of GBM with a high level of SAMSN1 expression was more likely to be over 4 cm (67.1% vs. 50%, p=0.075), and the boundary of the tumor was more likely to be unclear (67.1% vs. 50%, p=0.075) There were no significant correlations found between SAMSN1 expression levels and other clinical characteristics (e.g., gender, age, history of seizure and intracranial hypertension, tumor necrosis, extent of resection, and adjuvant radiotherapy or chemotherapy) (p>0.1, Table 3).