It was found that high SAMSN1 expression levels were a strong risk factor for PFS of GBM patients (HR=2.119, 95% CI 1.338-3.356, p=0.001), and post-surgical radiotherapy was a strong protective factor for PFS of GBM patients (HR=0.580, 95% CI 0.374-0.901, p=0.015). The gene discussed is SAMSN1; the disease is glioblastoma.