Among the different aPL, 9 were positive for lupus anticoagulant, 5 for anti-cardiolipin antibodies, 3 for anti-β2Glycoprotein I antibodies, 10 for annexin V antibodies and in total, 20 patients had one or more acquired thrombophilia markers. This evidence concerns the gene ANXA5 and Rare hereditary thrombophilia.