These findings are similar to those of Laude et al [10] who showed that the MP’s prothrombotic activity is much higher in women with RPL when compared to non- pregnant healthy controls using prothrombinase assay by capture of MPs on immobilized annexin V. Carp et al [11] also showed that endothelial MPs are increased in women with recurrent miscarriage which is contradictory to the report by Alijotas Reig et al [12] who have shown a significant decrease in endothelial MPs in whole group of PL as also with recurrent miscarriage group. The gene discussed is ANXA5; the disease is spontaneous abortion.