As shown in Figure 6, saponin 1 treatment significantly induced Bax expression and inhibited Bcl-2 expression in both glioblastoma cell lines (38.5 ± 4.8% and 27.1 ± 2.5% in U251MG and U87MG cells, respectively), resulting in a decreased Bcl-2/Bax ratio when compared with the vehicle controls (Figure 6B and 6C). The gene discussed is BAX; the disease is glioblastoma.