It has been shown that the inactivation of many essential enzymes in the pro-survival signaling pathways, including the Phosphoinositide 3-kinase (PI3K)/Protein Kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway [10] and the NF-κB signaling pathway, and the down-regulation of some key apoptotic mediators in the IAP family and Bcl-2 family contribute principally to the inhibition of cancer cell proliferation and the induction of apoptosis by these active compounds. The gene discussed is AKT1; the disease is cancer.