PTEN and neoplasm: Although we did not evaluate TGFβ-induced modulation of phosphorylation of the PTEN C-terminus in non-malignant epithelial cells, recent studies have also suggested that tissue fibroblasts with decreased PTEN activity might accelerate the development of tumors, indicating the importance of PTEN activity in not only tumor cells themselves but also cellular components of the tumor microenvironment [1,51].