PTEN and lung cancer: To elucidate a critical role of phosphorylation of the PTEN C-terminus in acquisition of TGFβ-induced malignant phenotypes, we established H358ON cells – lung cancer cells with a Dox-dependent gene expression system- in which GFP, GFP-PTENWt, or GFP-PTEN4A expression was induced only when Dox was added.